Alb-Cre
2022-11-19
B6.Cg-Tg(Alb-cre)21Mgn/J
品系编号:GAP1036
品系简称:Alb-Cre
品系特点:
Alb-cre 是通过转基因方式构建获得, 主要用于肝脏组织Cre-loxp系统研究使用。
遗传学信息:
遗传背景:C57BL/6J
品系类型:Transgenic
相关基因:Alb-Cre
饲养信息:
配繁策略:
Homozygote x Homozygote
配繁特性:
该小鼠可以用纯合子繁殖,毛色为黑色。
alb-cre
应用领域:
1、用于肝脏组织的 Cre-lox系统应用。
参考文献:
1、Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor.Kalinichenko VV , et al.Genes Dev 18(7):830-50
2、Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Stiles B , et al.Proc Natl Acad Sci U S A 101(7):2082-7
3、Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. Gu J , et al.J Biol Chem 278(28):25895-901